Publications
Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome
Seo SS*, Louros SR*, Anstey N, Gonzales-Lozano MA, Harper CB, Verity NC, Dando O, Thomson SR, Darnell JC, Kind PC, Li KW, and Osterweil EK. Excess ribogenesis unbalances translation in a model of Fragile X Syndrome. Nat Commun. 2022 Jun 10;13(1):3236. doi: 10.1038/s41467-022-30979-0. PubMed PMID: 35688821.
Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes
Barnes, SA, Thomazeau, A, Finnie, P, Heinrich, M, Heynen, A, Komiyama, N, Grant, S, Menniti, FS, Osterweil, E, and Bear, MF. Metabotropic signalling through the NMDA receptor carboxyterminal domain alters dendritic spine morphology and reverses fragile X phenotypes in mouse hippocampus. Cell Rep. 2025 Mar 25;44(3):115311. doi: 10.1016/j.celrep.2025.115311. Epub 2025 Feb 20. PMID: 39983718.
Cell type-specific translation profiling reveals a novel strategy for treating fragile X syndrome
Sophie R. Thomson*1,2, Sang S. Seo*1,2, Stephanie A. Barnes✝1,2, Susana R. Louros✝1,2, Melania Muscas1,2, Owen Dando1,2, Caomihe Kirby1,2, David J.A. Wyllie1,2, Giles E. Hardingham1,2,3, Peter C. Kind1,2, and Emily K. Osterweil1,2
Key roles of C2/GAP enzymatic domains in SYNGAP1 related pathophysiology.
Katsanevaki D*, Till SM*, Buller-Peralta I, Nawaz MS, Louros SR, Kapgal V, Tiwari S, Anstey NJ, Watson TC, Booker SA, W Darren, KN Dissanayake, Mizen LAM, Dimitrov S, Jackson AD, Arkell D, Biswal S, Perentos N, Jones MW, Cousin MA, Osterweil EK, Chattarji S, Wyllie DJA, Gonzalez-Sulser A, Hardt O, Wood ER, Kind PC.
Excessive proteostasis contributes to pathology in fragile X syndrome
Susana R Louros 1 , Sang S Seo 1 , Beatriz Maio 1 , Cristina Martinez-Gonzalez 1 , Miguel A Gonzalez-Lozano 2 , Melania Muscas 1 , Nick C Verity 1 , Jimi C Wills 3 , Ka Wan Li 2 , Matthew F Nolan 1 , Emily K Osterweil 4
Syngap+/- CA1 pyramidal neurons exhibit upregulated translation of long mRNAs associated with LTP.
Singh, A, Rizzi, M, Seo, S and Osterweil EK.
Identification of sound-activated neurons in the inferior colliculus by cFos immunostaining
Maio, B, Elu, N, Martinez-Gonzalez, C, Nolan, MF, *Osterweil, EK and *Louros, SR.
A differential effect of lovastatin versus simvastatin in neurodevelopmental disorders
Melania Muscas 1 , Susana R Louros 1 , Emily K Osterweil 2
FMR1 reduction alters cellular and circuit properties in human cortex
Singh A, Abbaspoor S, Chung L, Heinrich MJ, Stone S, Lidov H, Maio B, Phuoc-Tran T, Yoon J, Teng J, Martinez-Reyes C, Hammarlund E, Xu X, Rotenberg A, Gavornik J, Ferguson B, Farrell JS, Osterweil EK. bioRxiv 2026 (preprint). doi: 10.64898/2026.03.11.711123
FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1-/y mice
Maio B, Singh A, Hector R, Gadalla K, Selfridge J, Aria F, Louros SR, Cobb SR, Osterweil EK. bioRxiv 2026 (preprint). doi: 10.64898/2026.06.12.731901
Sustained correction of associative learning deficits following brief, early treatment in a rat model of Fragile X Syndrome
Asiminas A, Jackson AD, Louros S, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, and Kind PC.