Nicholas C. Verity, PhD

Postdoctoral Fellow

Centre for Discovery Brain Sciences

University of Edinburgh

Hugh Robson Building, George Square

Edinburgh, EH8 9XD

Email: Nicholas.Verity@ed.ac.uk

Education and Academic Positions        

 

  • Ph.D. in Neurotoxicology, MRC Toxicology Unit, University of Leicester

  • B.Sc in Biochemistry, University of York

Publications

  • Halliday M, Radford H, Zents KAM, Verity NC, Smith E, Ortori CA, Barrett DA, Bushell M and Mallucci GR. Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain 2017; 140(6); 1768-1783.

  • Bradley S, Bourgognon JM, Sanger H, Verity N, Mogg A, White D, Butcher A, Moreno JA, Molloy C, Macedo-Hatch T, Edwards J, Wess J, Pawlak R, Read DJ, Sexton P, Broad L, Steinert J, Mallucci GR, Christopoulos A, Felder C and Tobin AB. M1-muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. J Clin Invest 2017; 127(2); 487-499.

  • Radford H, Moreno JA, Verity N, Halliday M and Mallucci GR.
    PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol 2015; 130(5): 633-642.

  • Halliday M, Radford H, Sekine Y, Moreno JA, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D and Mallucci GR. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death & Disease 2015; 6:e1672.

  • Peretti D, Bastide A, Verity N, Guerra Martin M, Molloy C, Moreno JA, Radford H, Steinert J, Dinsdale D, Willis AE and Mallucci GR. RBM3 mediates structural plasticity and the protective effects of cooling in neurodegenerative disease. Nature 2015; 518: 236-239.

  • Verity N and Mallucci GR. Update on the pathophysiology of prion diseases (Review). ACNR 2014; V14(4);6-8.

  • Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Willis AE, Ortori CA, Barrett DA, Fischer PM and Mallucci GR. Oral treatment targeting the unfolded protein response prevents prion neurodegeneration and clinical disease in mice. Sci Trans Med 2013; 5:206ra138.

  • Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Guerra Martin M, Halliday M, Morgan J,Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M and Mallucci GR. Sustained translational repression by eIF2α−P mediates prion neurodegeneration. Nature 2012; 485: 507-511.

  • Verity N and Mallucci GR. Rescuing neurons in prion disease (Review). Biochem J 2010; 433:19-29.

  • Osterlab

Osterweil Lab,

University of Edinburgh