Callista B. Harper, PhD

Postdoctoral Fellow

Centre for Discovery Brain Sciences

University of Edinburgh

Hugh Robson Building, George Square

Edinburgh, EH8 9XD

Email: Callista.Harper@ed.ac.uk

Education and Academic Positions        

 

  • Postdoctoral Fellow, University of Edinburgh

  • Ph.D. Neuroscience, University of Queensland, Australia

  • B.Sc Biomedical Science & Pharmacology, University of Queensland, Australia

Publications

Refereed research publications

  • Harper CB, Mancini GMS, van Slegtenhorst M, Cousin MA. (2017) Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder. Neurobiol Dis. 108:298-306.

  • Joensuu M, Padmanabhan P, Durisic N, Bademosi AT, Cooper-Williams E, Morrow IC, Harper CB, Jung W, Parton RG, Goodhill GJ, Papadopulos A, Meunier FA. (2016) Subdiffractional tracking of internalized molecules reveals heterogenous motion states of synaptic vesicles. J Cell Biol 215:277-292.

  • Wang T, Martin S, Nguyen TH, Harper CB, Gormal RS, Martínez-Mármol R, Karunanithi S, Coulson EJ, Glass NR, Cooper-White JJ, van Swinderen B, Meunier FA. (2016) Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nat Commun 7:12976.

  • Kasula R, Chai YJ, Bademosi AT, Harper CB, Gormal RS, Morrow IC, Hosy E, Collins BM, Choquet D, Papadopulos A, Meunier FA. (2016) The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. J Cell Biol 214:847-58.

  • Gordon SL, Harper CB, Smillie KJ, Cousin MA. (2016) A fine balance of synaptophysin levels underlies efficient retrieval of synaptobrevin II to synaptic vesicles. PLoS One 11:e014957.

  • Harper CB, Papadopulos A, Martin S, Matthews DR, Morgan GP, Nguyen TH, Wang T, Nair D, Choquet D, Meunier FA. (2016) Botulinum neurotoxin type-A enters a nonrecycling pool of synaptic vesicles. Sci Rep 6:19654.

  • Wang T, Martin S, Papadopulos A, Harper CB, Mavlyutov TA, Niranjan D, Glass NR, Cooper-White JJ, Sibarita JB, Choquet D, Davletov B, Meunier FA. (2015) Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a. J Neurosci 35:6179-94.

  • Lin MH, Sivakumaran H, Jones A, Li D, Harper C, Wei T, Jin H, Rustanti L, Meunier FA, Spann K, Harrich D. (2014) A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1. Retrovirology 11:121. doi: 10.1186/s12977-014-0121-9.

  • Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B. (2013) Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjug Chem 24:1750-9.

  • Martin S*, Harper CB*, May LM, Coulson EJ, Meunier FA, Osborne SL. (2013) PIKfyve inhibition dysregulates autophagic trafficking and leads to apoptosis-independent neuronal cell death. PLoS One 8:e60512.
    *both authors contributed equally to the work

  • Harper CB, Martin S, Nguyen TH, Daniels SJ, Lavidis NA, Popoff MR, Hadzic G, Mariana A, Chau N, McCluskey A, Robinson PJ, Meunier FA. (2011) Dynamin inhibition blocks botulinum neurotoxin type-A endocytosis in neurons and delays botulism. J Biol Chem. 286:35966-76. Featured in F1000 and SciBX
     

Reviews & Other Publications

  • Harper CB, McCluskey A, Robinson PJ, Meunier FA. (2015) Exploiting endocytic pathways to prevent bacterial toxin infection. In The Comprehensive Sourcebook of Bacterial Protein Toxins, Alouf J, Ladant, D Popoff MR (eds) 1072-94.

  • Harper CB, Bademosi AT, Coulson EJ, Meunier FA. (2014) A role for SNAREs in neuronal survival? J Neurochem 129:753-5.

  • Harper CB, Popoff MR, McCluskey A, Robinson PJ, Meunier FA. (2013) Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Trends Cell Biol. 23:90-101.

  • Barry D, Roque H, Dumoux M, Kriston-Vizi J, Bodea GO, Harper C. (2013) Meeting report - imaging in cell biology: where next? J Cell Sci. 126:43-4.

  • Harper CB, Meunier FA. Botulism Paralysed. Australasian Science. April 2012.

  • Osterlab

Osterweil Lab,

University of Edinburgh